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Background: |
The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell . Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis . KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons . Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein with abundant expression in heart and skeletal muscle . Tyrosine phosphorylation is a putative regulator of KIF1C mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum. KIF1C is capable of forming homodimers and can noncovalently associate with 14-3-3 beta, gamma, epsilon and zeta . In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
KIF1C |
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Immunogen: |
Fusion protein of human KIF1C |
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Full name: |
kinesin family member 1C |
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Synonyms： |
SAX2; LTXS1; SATX2; SPAX2; SPG58 |
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SwissProt: |
O43896 |
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ELISA Recommended dilution: |
2000-5000 |
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IHC positive control: |
Human placenta and human sarcoma |
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IHC Recommend dilution: |
50-200 |
