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Background: |
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo or four extracellular immunoglobulin domains, a transmembrane domain, and 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
LILRB2 |
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Immunogen: |
Fusion protein of human LILRB2 |
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Full name: |
leukocyte immunoglobulin like receptor B2 |
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Synonyms: |
ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10 |
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SwissProt: |
Q8N423 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer and Human lung cancer |
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IHC Recommend dilution: |
50-200 |
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WB Predicted band size: |
65 kDa |
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WB Positive control: |
Hela cell, Raji cell, HepG2 cell lysates |
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WB Recommended dilution: |
500-2000 |
