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021-54888888/15800441009
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Background: |
The nuclear lamina consists of a 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo types, A and B. This gene encodes one of the 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
LMNB1 |
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Immunogen: |
Fusion protein of human LMNB1 |
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Full name: |
lamin B1 |
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Synonyms： |
LMN; ADLD; LMN2; LMNB |
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SwissProt: |
P20700 |
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ELISA Recommended dilution: |
2000-10000 |
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IHC positive control: |
Human cervical cancer and human thyroid cancer |
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IHC Recommend dilution: |
100-300 |
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WB Predicted band size: |
67 kDa |
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WB Positive control: |
Hela and HT-29 cells, human fetal liver tissue and 231 cells, K562 cells and human bladder transitional cells carcinoma tissue |
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WB Recommended dilution: |
1000-5000 |
