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Background: |
SSAT2 (spermidine/spermine N1-acetyltransferase family member 2), also known as diamine acetyltransferase 2, polyamine N-acetyltransferase 2 or thialysine N-epsilon-acetyltransferase, is a 170 amino acid protein that exists as a homodimer and belongs to the acetyltransferase family. Localizing to cytoplasm, SSAT2 is found in bone, cervix, ovary and pineal gland. SSAT2, which shares 46% amino acid identity to SSAT1, is expressed in many of the same tissues as SSAT1, however SSAT1 is more widely expressed. SSAT2 contains one N-acetyltransferase domain and functions as an enzyme, catalyzing the acetylation of polyamines, and may also act as a transciptional co-activator. SSAT2 promotes ubiquitination of HIF-1alpha by stabilizing the interaction of Elongin C and VHL. The gene encoding SSAT 2 maps to human chromosome 17p13.1. |
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Applications: |
WB, IF, FC |
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Name of antibody: |
SAT2 |
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Immunogen: |
Fusion protein of human SAT2 |
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Full name: |
spermidine/spermine N1-acetyltransferase family member 2 (SAT2) |
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Synonyms: |
SSAT2 |
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SwissProt: |
Q96F10 |
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WB Predicted band size: |
19 kDa |
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WB Positive control: |
HepG2, Hela, SVT2, COS7 cell lysates |
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WB Recommended dilution: |
200-1000 |
