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Background: |
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]. |
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Applications: |
WB, IHC |
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Name of antibody: |
PCBP1 |
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Immunogen: |
Fusion protein of human PCBP1 |
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Full name: |
poly(rC) binding protein 1 (PCBP1) |
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Synonyms: |
HEL-S-85; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX |
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SwissProt: |
Q15365 |
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IHC positive control: |
carcinoma of human kidney tissue and adenocarcinoma of human ovary tissue; carcinoma of human pancreas tissue and human prostate tissue |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
37 kDa |
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WB Positive control: |
Hela, HepG2, K562, MCF-7, SVT2 cell, Human liver tissue, Human ovary tissue, Human brain tissue lysates |
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WB Recommended dilution: |
500-2000 |
