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中文名称： APIP 抗原（重组蛋白）
别 名： APAF1 interacting protein; APIP2, CGI29, CGI-29, MMRP19, dJ179L10.2
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Full name: |
APAF1 interacting protein |
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Synonyms: |
APIP2, CGI29, CGI-29, MMRP19, dJ179L10.2 |
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Swissprot: |
Q96GX9 |
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Gene Accession: |
BC008440 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury.The protein highly expressed in skeletal muscle and heart and binds to the CARD of Apaf-1 in competition with caspase-9. Exogenous APIP inhibits cytochrome c-induced activation of caspase-3 and caspase-9, and suppresses cell death triggered by mitochondrial apoptotic stimuli through inhibiting the downstream activity of cytochrome c released from mitochondria. |
