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021-54845833/15800441009
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Background: |
Members of the AB hydrolase superfamily have diverse catalytic functions and play a crucial role in the metabolism of lipids. DAGLβ (diacylglycerol lipase beta), also known as KCCR13L, is a 672 amino acid multi-pass membrane protein that belongs to the AB hydrolase superfamily. DAGLβ uses calcium as a cofactor to catalyze the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), a reaction that is required for axonal growth and for retrograde synaptic signaling at mature synapses. DAGLβ functions at an optimal pH of 7 and its activity is inhibited by p-hydroxy-mercuri-benzoate and HgCl2, but not PMSF. There are three isoforms of DAGLβ that are produced as a result of alternative splicing events. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
DAGLB |
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Immunogen: |
Synthetic peptide of human DAGLB |
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Full name: |
diacylglycerol lipase beta |
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Synonyms: |
KCCR13L; DAGLBETA |
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SwissProt: |
Q8NCG7 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer |
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IHC Recommend dilution: |
20-100 |
