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Background: |
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
DCX |
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Immunogen: |
Synthetic peptide of human DCX |
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Full name: |
doublecortin |
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Synonyms： |
DC; DBCN; LISX; SCLH; XLIS |
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SwissProt: |
O43602 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer and human esophagus cancer |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
49 kDa |
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WB Positive control: |
Human fetal brain tissue and 293T，K562，Jurkat cell |
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WB Recommended dilution: |
500-2000 |
