购物车
帮助
021-54888888/15800441009
中文名称：PRKAA2 抗原（重组蛋白）
英文名称： PRKAA2 Antigen (Recombinant Protein)
别 名： protein kinase, AMP-activated, alpha 2 catalytic subunit; AMPK; AMPK2; PRKAA; AMPKa2
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 16-268 amino acids of human PRKAA2 |
|
Full name: |
protein kinase, AMP-activated, alpha 2 catalytic subunit |
|
Synonyms: |
AMPK; AMPK2; PRKAA; AMPKa2 |
|
Swissprot: |
P54646 |
|
Gene Accession: |
BC069680 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. |
