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021-54845833/15800441009
中文名称：兔抗DDIT4多克隆抗体
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Background: |
REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thought to function in the regulation of reactive oxygen species (ROS). REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level. REDD-1 negatively regulates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP. It is crucial in the coupling of extra- and intracellular cues to FRAP regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
DDIT4 |
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Immunogen: |
Fusion protein of human DDIT4 |
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Full name: |
DNA-damage-inducible transcript 4 |
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Synonyms： |
Dig2; REDD1; REDD-1 |
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SwissProt: |
Q9NX09 |
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ELISA Recommended dilution: |
2000-5000 |
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IHC positive control: |
Human liver cancer and human gastric cancer |
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IHC Recommend dilution: |
50-200 |
