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中文名称：NTAN1抗原（重组蛋白）
英文名称： NTAN1 Antigen (Recombinant Protein)
别 名： PNAA; PNAD
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 1-310 amino acids of human NTAN1 |
|
Full name: |
N-terminal asparagine amidase |
|
Synonyms: |
PNAA; PNAD |
|
Swissprot: |
Q96AB6 |
|
Gene Accession: |
BC017336 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. |
