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中文名称：EIF3C 抗原（重组蛋白）
英文名称： EIF3C Antigen (Recombinant Protein)
别 名： eukaryotic translation initiation factor 3 subunit C; EIF3CL; EIF3S8; eIF3-p110
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to a region derived from 714-913 amino acids of human EIF3C |
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Full name: |
eukaryotic translation initiation factor 3 subunit C |
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Synonyms: |
EIF3CL; EIF3S8; eIF3-p110 |
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Swissprot: |
Q99613 |
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Gene Accession: |
BC001571 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). |
