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021-54888888/15800441009
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Background: |
EID3 is highly expressed in testis and shows homology to a region of EID1 implicated in binding to CBP/p300. EID3 acts as a potent inhibitor of nuclear receptor transcriptional activity by a mechanism that is independent of direct interactions with nuclear receptors, including SHP. Furthermore, EID3 directly binds to and blocks the SRC-1 interacting domain of CBP, which has been implicated to act as the interaction surface for nuclear receptor co-activators. Consistent with this idea, EID3 prevents recruitment of CBP to a natural nuclear receptor-regulated promoter. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
EID3 |
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Immunogen: |
Synthetic peptide of human EID3 |
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Full name: |
EP300 interacting inhibitor of differentiation 3 |
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Synonyms: |
NS4EB; NSE4B; NSMCE4B |
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SwissProt: |
Q8N140 |
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IHC positive control: |
Human gastric cancer and human thyroid cancer |
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IHC Recommend dilution: |
25-100 |
