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Background: |
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. |
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Applications: |
WB |
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Name of antibody: |
EIF2S2(Ab-67) |
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Immunogen: |
Synthesized peptide derived from N-terminal of human eIF2B. |
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Full name: |
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa |
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Synonyms： |
EIF2; EIF2B; PPP1R67; EIF2beta; eIF-2-beta |
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SwissProt: |
P20042 |
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WB Predicted band size: |
38 kDa |
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WB Positive control: |
K562 cells lysate |
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WB Recommended dilution: |
500-3000 |
