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英文名称： RBM8A Antigen (Recombinant Protein)
相关类别： 抗原
概 述
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Full name: |
RNA binding motif protein 8A |
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Synonyms: |
TAR; Y14; RBM8; ZNRP; RBM8B; ZRNP1; BOV-1A; BOV-1B; BOV-1C; MDS014; DEL1q21.1; C1DELq21.1 |
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Swissprot: |
Q9Y5S9 |
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Gene Accession: |
BC017088 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo alternate translation start codons with this gene, which result in 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome. |
