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021-54888888/15800441009
中文名称： 兔抗UPF3A多克隆抗体
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Background: |
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
UPF3A |
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Immunogen: |
Synthetic peptide of human UPF3A |
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Full name: |
UPF3A regulator of nonsense mediated mRNA decay |
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Synonyms: |
UPF3; HUPF3A; RENT3A |
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SwissProt: |
Q9H1J1 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human colorectal cancer and Human lung cancer |
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IHC Recommend dilution: |
20-100 |
