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Background: |
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. |
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Applications: |
WB |
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Name of antibody: |
ST5 |
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Immunogen: |
Synthesized peptide derived from internal of human ST5. |
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Full name: |
suppression of tumorigenicity 5 |
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Synonyms： |
HTS1; p126; DENND2B |
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SwissProt: |
P78524 |
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WB Predicted band size: |
126 kDa |
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WB Positive control: |
COLO205 cells lysate |
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WB Recommended dilution: |
500-3000 |
