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021-54845833/15800441009
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Background: |
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. |
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Applications: |
WB |
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Name of antibody: |
STAT2 (phospho-Tyr690) |
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Immunogen: |
Synthetic peptide of human STAT2 (phospho-Tyr690) |
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Full name: |
signal transducer and activator of transcription 2, 113kDa (phospho-Tyr690) |
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Synonyms： |
P113; ISGF-3; STAT113 |
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SwissProt: |
P52630 |
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WB Predicted band size: |
98 kDa |
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WB Positive control: |
Hela cells treated with IFN-α |
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WB Recommended dilution: |
500-1000 |
