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中文名称： CASP5 抗原（重组蛋白）
英文名称： CASP5 Antigen (Recombinant Protein)
别 名： caspase 5, apoptosis-related cysteine peptidase; ICH-3; ICEREL-III; ICE(rel)III
相关类别：抗原
概 述
技术规格
Full name:
caspase 5, apoptosis-related cysteine peptidase
Synonyms:
ICH-3; ICEREL-III; ICE(rel)III
Swissprot:
P51878
Gene Accession:
BC113406
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation ne金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingork important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
