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中文名称： CCM2 抗原（重组蛋白）
英文名称：CCM2 Antigen (Recombinant Protein)
别 名： CCM2 scaffolding protein; OSM; C7orf22; PP10187
储 存： 冷冻（-20℃）
相关类别：抗原
技术规格
|
Full name: |
CCM2 scaffolding protein |
|
Synonyms: |
OSM; C7orf22; PP10187 |
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Swissprot: |
Q9BSQ5 |
|
Gene Accession: |
BC004903 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. |
