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中文名称： RNF128 抗原（重组蛋白）
英文名称： RNF128 Antigen (Recombinant Protein)
别 名： ring finger protein 128; GRAIL
储 存： 冷冻（-20℃）
概 述
技术规格
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Full name: |
ring finger protein 128 |
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Synonyms: |
GRAIL |
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Swissprot: |
Q8TEB7 |
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Gene Accession: |
BC063404 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
