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021-54845833/15800441009
中文名称：兔抗ZAP70多克隆抗体
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Background: |
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
ZAP70 |
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Immunogen: |
Fusion protein of human ZAP70 |
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Full name: |
zeta chain of T cell receptor associated protein kinase 70 |
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Synonyms: |
SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70 |
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SwissProt: |
P43403 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human cervical cancer |
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IHC Recommend dilution: |
50-300 |
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WB Predicted band size: |
70 kDa |
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WB Positive control: |
Mouse liver tissue and Jurkat cell lysates |
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WB Recommended dilution: |
500-2000 |
