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021-54888888/15800441009
中文名称：TFEB 抗原（重组蛋白）
英文名称：TFEB Antigen (Recombinant Protein)
别 名： transcription factor EB; TCFEB; BHLHE35; ALPHATFEB
储 存： 冷冻（-20℃）
相关类别：抗原
概 述
技术规格
|
Full name: |
transcription factor EB |
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Synonyms: |
TCFEB; BHLHE35; ALPHATFEB |
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Swissprot: |
P19484 |
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Gene Accession: |
BC032448 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1. |
