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Background: |
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. |
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Applications: |
ELISA, WB |
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Name of antibody: |
IL1B |
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Immunogen: |
Fusion protein of human IL1B |
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Full name: |
interleukin 1 beta |
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Synonyms: |
IL-1; IL1F2; IL1-BETA |
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SwissProt: |
P01584 |
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ELISA Recommended dilution: |
5000-10000 |
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WB Predicted band size: |
31 kDa |
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WB Positive control: |
Human fetal liver tissue lysate |
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WB Recommended dilution: |
500-2000 |
