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021-54888888/15800441009
抗 原： PDHA1
技术规格
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Background: |
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link be金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingeen glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo alpha and 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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Applications: |
WB, IF |
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Name of antibody: |
PDHA1 |
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Immunogen: |
Fusion protein of human PDHA1 |
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Full name: |
pyruvate dehydrogenase E1 alpha 1 subunit |
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Synonyms: |
PDHA; PDHAD; PHE1A; PDHCE1A |
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SwissProt: |
P08559 |
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WB Predicted band size: |
43 kDa |
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WB Positive control: |
293, 1299, mEsc and Tc1 cell lysates |
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WB Recommended dilution: |
1000-5000 |
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IF positive control: |
Hela cells |
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IF Recommend dilution: |
50-100 |
