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021-54845833/15800441009
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Full name: |
ring finger and CHY zinc finger domain containing 1 |
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Synonyms: |
ZCHY; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; PRO1996 |
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Swissprot: |
Q96PM5 |
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Gene Accession: |
BC047393 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
