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中文名称： UNC45B 抗原（重组蛋白）
英文名称： UNC45B Antigen (Recombinant Protein)
别 名： unc-45 myosin chaperone B; CMYA4; UNC45; CTRCT43; SMUNC45; UNC-45B
相关类别： 抗原
储 存： 冷冻（-20℃）
概 述
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Full name: |
unc-45 myosin chaperone B |
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Synonyms: |
CMYA4; UNC45; CTRCT43; SMUNC45; UNC-45B |
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Swissprot: |
Q8IWX7 |
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Gene Accession: |
BC101063 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. |
