金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meeting

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      • 品牌 : 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meeting生物
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    中文名称: UBE2E2抗原(重组蛋白)

    英文名称: UBE2E2 Antigen (Recombinant Protein)

    别      名: UBCH8

    相关类别: 抗原

    储      存: 冷冻(-20℃)

    概述

    Full length fusion protein

    技术规格

    Full name:

    ubiquitin conjugating enzyme E2E 2

    Synonyms:

    UBCH8

    Swissprot:

    Q96LR5

    Gene Accession:

    BC022332

    Purity:

    >85%, as determined by Coomassie blue stained SDS-PAGE

    Expression system:

    Escherichia coli

    Tags:

    His tag C-Terminus, GST tag N-Terminus

    Background:

    Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). The first step in the ubiquitination process requires the ATP-dependent activation of the ubiquitin C-terminus and the assembly of multi-ubiquitin chains by the E1 enzyme. The ubiquitin chain is then conjugated to the E2 enzyme to generate an intermediate ubiquitin-E2 complex. The E3 enzyme then catalyzes the transfer of ubiquitin from E2 to the appropriate protein substrate, thereby targeting that substrate for degradation. A wide range of enzymes facilitate this proteolytic ubiquitin pathway, one of which is UBE2E2 (also known as UBCH8 in human), which functions as an E2 enzyme and catalyzes the ATP-dependent covalent attachment of ubiquitin to target proteins, thereby playing an important role in protein degradation.

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