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中文名称： IPO4 抗原（重组蛋白）
英文名称： IPO4 Antigen (Recombinant Protein)
别 名： importin 4; Imp4
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
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Fusion protein corresponding to C terminal 250amino acids of human IPO4 |
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Full name: |
importin 4 |
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Synonyms: |
Imp4 |
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Swissprot: |
Q8TEX9 |
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Gene Accession: |
BC003690 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. |
