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Background: |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. |
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Applications: |
ELISA, WB |
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Name of antibody: |
FBXO8 |
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Immunogen: |
Fusion protein of human FBXO8 |
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Full name: |
F-box protein 8 |
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Synonyms: |
FBS; DC10; FBX8 |
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SwissProt: |
Q9NRD0 |
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ELISA Recommended dilution: |
5000-10000 |
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WB Predicted band size: |
37 kDa |
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WB Positive control: |
Raji cell lysate |
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WB Recommended dilution: |
500-2000 |
