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中文名称：小鼠抗HDAC3单克隆抗体
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Background: |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. |
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Applications: |
WB |
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Name of antibody: |
HDAC3 |
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Immunogen: |
Fusion protein of human HDAC3 |
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Full name: |
histone deacetylase 3 |
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Synonyms: |
HD3; RPD3; RPD3-2 |
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SwissProt: |
O15379 |
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WB Predicted band size: |
49 kDa |
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WB Positive control: |
THP-1, LNCAP, MCF7, PC12, 293, Jurkat, 3T3 and Hela cell lysates |
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WB Recommended dilution: |
1000-5000 |
