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Full name: |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta |
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Synonyms: |
TA-NFKBH, IkappaBNS |
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Swissprot: |
Q8NI38 |
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Gene Accession: |
BC006273 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes.IκBNS, the nuclear IκB-like protein encoded by Nfkbid, is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens.IκBNS has been identified as a member of the IκB family of NF-κB inhibitors, which undergoes induction upon TCR signaling. IκBNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine. |
