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中文名称：MPZL1抗原（重组蛋白）
英文名称 MPZL1 Antigen (Recombinant Protein)
别 名： PZR; PZRa; PZRb; PZR1b; MPZL1b
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 70-269 amino acids of human MPZL1 |
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Full name: |
myelin protein zero like 1 |
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Synonyms: |
PZR; PZRa; PZRb; PZR1b; MPZL1b |
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Swissprot: |
O95297 |
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Gene Accession: |
BC007881 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. |
