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中文名称： CISH 抗原（重组蛋白）
英文名称： CISH Antigen (Recombinant Protein)
别 名： cytokine inducible SH2 containing protein; CIS; G18; SOCS; CIS-1; BACTS2
相关类别：抗原
储 存： 冷冻（-20℃）
概 述
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Full name: |
cytokine inducible SH2 containing protein |
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Synonyms: |
CIS; G18; SOCS; CIS-1; BACTS2 |
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Swissprot: |
Q9NSE2 |
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Gene Accession: |
BC031590 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. |
