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021-54888888/15800441009
别 名： immunoglobulin heavy constant alpha 1; IgA1
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Background: |
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915). |
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Applications: |
ELISA, IHC |
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Name of antibody: |
IGHA1 |
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Immunogen: |
Fusion protein of human IGHA1 |
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Full name: |
immunoglobulin heavy constant alpha 1 |
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Synonyms: |
IgA1 |
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SwissProt: |
P01876 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human cervical cancer and Human colorectal cancer |
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IHC Recommend dilution: |
50-300 |
