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中文名称： FGFRL1抗原（重组蛋白）
英文名称： FGFRL1 Antigen (Recombinant Protein)
别 名： FHFR; FGFR5
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to N terminal 172 amino acids of human FGFRL1 |
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Full name: |
fibroblast growth factor receptor-like 1 |
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Synonyms: |
FHFR; FGFR5 |
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Swissprot: |
Q8N441 |
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Gene Accession: |
NP_068742 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved be金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingeen members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference be金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingeen this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. |
