购物车
帮助
021-54888888/15800441009
中文名称：ERH抗原（重组蛋白）
英文名称： ERH Antigen (Recombinant Protein)
别 名： DROER
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 1-104 amino acids of human ERH |
|
Full name: |
ERH, mRNA splicing and mitosis factor |
|
Synonyms: |
DROER |
|
Swissprot: |
P84090 |
|
Gene Accession: |
BC014301 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
ERH (enhancer of rudimentary homolog), also known as DROER, is a 104 amino acid transcriptional coregulator that is ubiquitously expressed and highly conserved among eukaryotes. ERH may play a role in cell cycle regulation and pyrimidine biosynthesis. ERH represses the function of the coactivator PCBD, preventing it from enhancing the activity of the tissue-specific transcription factor HNF-1 (hepatocyte nuclear factor-1). HNF-1 is a homeodomain transcription factor that binds DNA as a dimer and the HNF-1/DNA complex is stabilized by PCBD. By repressing PCBD, ERH disrupts the stability of the HNF-1/DNA complex, affecting the expression of multiple genes in the liver. The structure of ERH is characterized by a single domain consisting of three alpha-helices and four beta-strands. ERH has a long flexible loop that is significantly conserved, suggesting that this loop region may be important for the function of ERH. ERH has 金年会·(jinnianhui)金字招牌诚信至上-Gold Annual Meetingo casein kinase II phosphorylation sites that are thought to disrupt the ability of ERH to dimerize. |
